Bills vs Rams Prediction and Betting Odds: Buffalo Bills to Win

Bills vs Rams Prediction and Betting Odds: Buffalo Bills is predicted to win the opening game of the NFL 2022-23 season against the Los Angeles Rams.

The 2022 NFL season is anticipated to be filled with adventures and nail-biting finishes. The regular season is set to flag off with the defending champions Los Angeles Rams hosting Buffalo Bills at the SoFi stadium.

The Rams would be looking to repeat their feat of becoming the first side to win the Super Bowl for two consecutive years since 2004 whereas the Bills have struggled big time in the postseason games in the last couple of seasons. Despite the Rams having the home advantage, it is the Buffalo side who are ahead to take their first victory on Thursday night.

Bills vs Rams Betting Odds

Buffalo Bills1.74
Los Angeles Rams2.14
Predicted WinnerBuffalo Bills

Bills vs Rams Prediction and Betting Odds: 2021 season and pre-season

The Los Angeles Rams did exceedingly well in the 2021 season where they emerged as the Super Bowl champions after a long gap. They finished the regular season with 12 victories in 17 games and as a result, went on to clinch the NFC West title.

In the playoffs, they defeated the Cardinals, Buccaneers, and 49ers before meeting the Bengals in the Super Bowl game. On the other hand, the pre-season hasn’t been kind to the defending champions as they suffered defeats in two out of three games.

On the other hand, the Buffalo Bills are in big need of that extra luck if they have to go all the way this season. Looking at their last season’s campaign, they won the AFC West division title comfortably with 11 victories in the regular season.

After making it to the playoffs, they won the wildcard against New England Patriots while losing the Divisional round affair against Kansas City Chiefs with the hope of winning the championship this season. Their 2022 pre-season was off to a dream start after triumphs against Colts and Broncos but a 21-0 loss against Panthers is alarming for the side.

Bills vs Rams Prediction and Betting Odds: Head-to-head

Matches: 13: Rams: 5 Bills: 8

Last meeting: Buffalo Bills defeated Rams 35-32 on 27th September 2020.

Bills vs Rams Prediction and Betting Odds: Players to watch


Bryce Perkins has been a huge contributor to the Bills’ success in the postseason with a 73.7% completion rate and 143 yards completed in 14 games.

He will be accompanied by Trey Ragas who has 1 attempt and 9 yards as a running back along with one rushing 1st downs in the regular season.

Lance McCutcheon who plays as the wide receiver has 32 receptions, 8 targets, and 4 receiving first downs in this edition. Grant Haley who is positioned at Safety has an overall 82 tackles and 12 assists.


Matt Barkley is the leader in passing with 2699 yards and a passer rating of 66.6 along with a completion percentage of 58.4% in the postseason. As far as Rushing is concerned,

Duke Johnson is the prime running back in the eleven with 330 yards and 18 rushing first downs in the previous season.

Neil Pauú is the leader in receiving aspect as the Tight end in the side with 46 receiving yards and a long reception of 26 in 4 appearances for the big man.

Jaquan Johnson who is the best defender in the eleven was on fire as he affected 26 tackles overall including 1 long interception.

Bills vs Rams Prediction and Betting Odds: Predicted Winner

Even though the Rams are the Super Bowl holders, the bookmarkers have put them as the underdogs in their first week, implying that the schedule for the champions isn’t going to be a stroll in the park. According to BettingExpert, the contest is neck to neck with the Bills narrowly tipped to win it. The reigning champions are given odds of 2.15 whereas the away side is provided with odds of 1.75 as of now.

The Oddscheker who accumulates the best odds has given a slightly better chance for the Bills with odds of 7/9 whereas the home team has 5/4 odds and the trend can likely reverse with still abundant time left for the clash. Smarkets also suggests that the result can go either way with teams fighting for the win until the last minute. It has gone to give odds of 2.14 to the Los Angeles side whereas the team on the road is given odds of 1.78.

Read :Jets vs Giants Prediction: Which team will continue the winning streak?

Bills vs Rams Prediction and Betting Odds


Subhash, Founder of Crowdwisdom360 is an MBA and a Trained Financial Advisor with an extensive background in Forecasting in Financial Services and Politics. He has appeared many times on National TV and has written for a variety of magazines on Wealth Management and Election Strategy.

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